17 Best Drugstore Makeup Setting Sprays

If there’s one product in your makeup routine that can make or break your look, it’s setting spray. Whether your foundation tends to fade after a few hours, your powder looks cakey, or your eyeshadow settles into fine lines, a good setting spray can help your makeup stay fresh, smooth, and vibrant all day.

For many of us, high-end sprays are tempting, but drugstore options often deliver amazing results without the premium price tag. You don’t need to spend a fortune to get long-lasting makeup that looks professional. Today, we’re diving into the 17 best drugstore makeup setting sprays, covering everything from lightweight sprays for natural makeup to mattifying sprays for oily skin and hydrating options for dry skin.

We’ll also go over:

• How to choose the right setting spray for your skin type

• Application tips for the best results

• Common mistakes that reduce effectiveness

Let’s start with why a setting spray is so important.

Why You Need a Makeup Setting Spray

A setting spray is essentially a finishing mist that locks in your makeup. Unlike powders, which can feel heavy or cake on mature skin, setting sprays provide a weightless finish that helps your makeup adhere to your skin longer.

Here’s what a setting spray does:

1. Locks in Makeup

It creates a light barrier over your makeup, reducing fading and smudging.

2. Reduces Powdery Appearance

Unlike heavy powders, setting sprays can eliminate that “chalky” look, leaving a natural finish.

3. Extends Wear Time

If you have a long day or special event, setting spray ensures your makeup looks fresh from morning until night.

4. Refreshes Skin Throughout the Day

Many sprays double as hydrating mists, giving a boost of moisture and a dewy finish.

5. Enhances Makeup Blending

Spritzing a small amount over powder can help blend makeup seamlessly for a softer, more natural look.

How to Choose the Right Setting Spray for Your Skin Type

Not all sprays are created equal. The right choice depends on your skin type and the finish you want:

For Oily Skin

Look for mattifying or oil-control sprays. These help prevent shine and reduce makeup slippage.

For Dry Skin

Opt for hydrating or dewy-finish sprays. They prevent makeup from looking cakey and keep your skin looking fresh.

For Combination Skin

Choose a balance spray that lightly hydrates without increasing oiliness in your T-zone.

For Mature Skin

Look for hydrating, fine-mist sprays that avoid emphasizing fine lines and help makeup settle naturally.

For Longevity

Some sprays are formulated for long-wear or 16-24 hour coverage, perfect for weddings, events, or long workdays.

How to Apply Makeup Setting Spray

Proper application ensures maximum results. Here’s a step-by-step guide:

1. Shake the bottle (if instructed) to mix the formula.

2. Hold 8-12 inches away from your face for an even mist.

3. Close your eyes and mouth to avoid getting product in them.

4. Spray in an X and T pattern:

   • X: across both cheeks diagonally

   • T: across forehead, down nose, and chin

5. Let it dry naturally — avoid rubbing your face.

6. Reapply lightly during the day if needed, especially hydrating sprays.

Pro tip: For a soft-focus effect, spray before powder to blend everything together, then spray again as a final step to set.

17 Best Drugstore Makeup Setting Sprays

Here’s a detailed list of the top drugstore setting sprays that perform well across skin types and budgets.

1. NYX Professional Makeup Setting Spray – Matte Finish

Why it works: Long-lasting matte finish, controls shine for oily skin.
Best for: Oily or combination skin looking to prevent mid-day shine.
Application tip: Use 3-4 spritzes after all makeup is applied; avoid heavy layering.

2. NYX Professional Makeup Setting Spray – Dewy Finish

Why it works: Lightweight hydration with a radiant finish.
Best for: Dry or dull skin that needs a luminous boost.
Application tip: Spray before powder for a natural glow or after for added hydration.

3. e.l.f. Matte Magic Mist & Set

Why it works: Affordable, mattifying, and lightweight; keeps makeup in place without feeling sticky.
Best for: Oily or combination skin for long wear.
Application tip: Can be used both before and after powder for extra longevity.

4. e.l.f. Makeup Mist & Set

Why it works: Dewy finish, hydrates, and sets makeup naturally.
Best for: Dry or mature skin that wants a soft, radiant finish.
Application tip: Hold the mist farther away for a sheer, natural glow.

5. L’Oreal Infallible Pro-Spray & Set Makeup Extender

Why it works: Lightweight, fragrance-free, and long-lasting.
Best for: All-day wear without sticky residue.
Application tip: Spray a thin layer for natural finish, more for special events.

6. Milani Make It Last Setting Spray

Why it works: Offers both long-wear and hydration, locking in makeup for 16 hours.
Best for: Any skin type, perfect for events or long workdays.
Application tip: Apply after makeup; reapply lightly if needed during hot days.

7. Wet n Wild Photo Focus Setting Spray – Matte Finish

Why it works: Affordable, controls shine, and keeps makeup photo-ready.
Best for: Oily skin or humid climates.
Application tip: Use sparingly on dry areas to prevent over-mattifying.

8. Wet n Wild Photo Focus Setting Spray – Dewy Finish

Why it works: Lightweight, adds glow without making skin greasy.
Best for: Dry, mature, or tired-looking skin needing a hydration boost.
Application tip: Hold farther away to mist evenly for a natural finish.

9. Milani Make It Dewy Setting Spray

Why it works: Hydrating, radiant finish that keeps makeup fresh all day.
Best for: Dry or dull skin needing extra luminosity.
Application tip: Use over powder to add glow without disrupting coverage.

10. CoverGirl TruBlend Fixing Spray

Why it works: Sets makeup and provides flexible wear for all skin types.
Best for: Everyday wear; lightweight finish.
Application tip: Use 3-4 spritzes after makeup for best results.

11. Rimmel Stay Matte Fixing Spray

Why it works: Long-lasting matte finish with excellent oil control.
Best for: Oily or combination skin; ideal for hot days.
Application tip: Spray lightly; too much can feel powdery on dry skin.

12. Hard Candy Sheer Envy Makeup Setting Spray

Why it works: Lightweight, dewy finish; refreshes makeup during the day.
Best for: Dry, combination, or mature skin.
Application tip: Can double as a mid-day refresher spray.

13. Milani Make It Last All Day Setting Spray

Why it works: Offers strong hold, long-lasting wear without heaviness.
Best for: Combination or oily skin; events requiring extended wear.
Application tip: Spray lightly for natural finish; layer for more staying power.

14. LA Girl Pro Setting Spray – Dewy Finish

Why it works: Hydrating and lightweight, enhances natural glow.
Best for: Dry or mature skin.
Application tip: Hold 10 inches from face and spray evenly in X and T pattern.

15. LA Girl Pro Setting Spray – Matte Finish

Why it works: Controls oil while keeping makeup fresh for hours.
Best for: Oily or combination skin needing long-lasting matte finish.
Application tip: Use sparingly in dry areas to avoid flaking.

16. Physicians Formula Argan Wear Setting Spray

Why it works: Infused with argan oil, hydrates while setting makeup.
Best for: Dry, sensitive, or mature skin that needs hydration plus longevity.
Application tip: Mist lightly over face; can also be used to refresh skin mid-day.

17. Jordana Make It Last Setting Spray

Why it works: Lightweight, flexible hold with affordable price point.
Best for: Daily wear, all skin types, beginners.
Application tip: Use as a final step to prevent fading or smudging.

Tips for Using Setting Spray Effectively

1. Distance matters: Hold 8-12 inches from the face for even coverage.

2. Layer strategically: Use a thin mist to lock in makeup without saturating it.

3. Blend before drying: If using powder or cream blush afterward, lightly tap primer or mist to blend.

4. Refresh mid-day: Hydrating sprays can revive makeup, especially in dry climates.

5. Avoid oversaturation: Too much product can make makeup slip or look wet.

Common Mistakes People Make With Setting Spray

• Using it as a replacement for primer: Setting spray locks in makeup but doesn’t replace primer for longevity or smoothness.

• Spraying too close: Can leave wet spots and disturb foundation.

• Skipping hydration: Dry skin needs a mist with humectants or water-based sprays.

• Overusing: Too many layers can feel sticky or mask-like.

Why Drugstore Sprays Are Worth It

Many drugstore setting sprays are formulated with the same high-performance ingredients as high-end options, including:

• Humectants like glycerin for hydration

• Silicones for smooth wear

• Film-forming agents for long-lasting hold

They are also more accessible, affordable, and easy to test, allowing you to try multiple options until you find your perfect fit.

Pro Tips for Mature Skin

1. Choose hydrating or dew-finish sprays to prevent fine lines from appearing dry.

2. Light misting works better than heavy spritzing — mature skin needs subtlety.

3. Pair with primer: primer + setting spray = maximum wear and smooth finish.

4. Keep a travel-size spray handy to refresh makeup throughout the day.

The best drugstore makeup setting sprays prove that you don’t need to spend a fortune for long-lasting, professional-looking makeup. From mattifying options for oily skin to dewy, hydrating mists for dry or mature skin, there is something for every type and every budget.

A good setting spray locks in makeup, keeps skin looking fresh, and prevents smudging or fading, making your beauty routine simpler and more effective. By selecting the right spray for your skin type and following proper application techniques, your makeup can stay flawless all day — without breaking the bank.

Invest in a few sprays from this list, test them in different conditions, and find the one that suits your lifestyle, skin type, and finish preference. Whether you want a natural glow, a matte finish, or long-lasting hold, drugstore setting sprays have you covered.

How to Choose the Perfect Drugstore Setting Spray for Your Skin Type

While drugstore sprays offer incredible variety, knowing your skin type and goals helps you pick the right one. Choosing wisely can be the difference between makeup that lasts all day and makeup that fades or smudges within hours.

Oily Skin

If your skin tends to get shiny during the day, especially around the T-zone, mattifying setting sprays are your best friend. Look for:

• Ingredients that absorb excess oil, such as silica or clay-based compounds

• Lightweight formulas that don’t feel heavy or sticky

• Long-wear claims (“12-hour” or “16-hour”) to control shine through workdays or outings

Pro Tip: Pair your mattifying spray with a light, oil-free primer and powder to extend longevity. Applying a thin mist over powder can help set everything without adding extra oiliness.

Dry or Mature Skin

Dry skin benefits from hydrating or dewy setting sprays. These sprays help:

• Keep skin from looking cakey or flaky

• Provide a soft, natural glow without emphasizing fine lines

• Add moisture back into the skin throughout the day

Look for sprays with ingredients like glycerin, hyaluronic acid, aloe vera, or botanical extracts.

Pro Tip: For mature skin, avoid heavy layers of matte powder. Instead, lightly mist your face with a hydrating spray after applying powder to melt the products together and create a more natural finish.

Combination Skin

Combination skin can be tricky, as the T-zone often gets oily while cheeks or jawlines remain dry. For this, balancing sprays are ideal. They often have a lightweight base that hydrates where needed but controls oil in problem areas.

Pro Tip: You can use a dual approach: mattifying spray on your T-zone and hydrating spray on drier areas, or choose a spray labeled suitable for all skin types that balances hydration and oil control.

Layering Setting Spray With Other Makeup Products

The effectiveness of a setting spray often depends on how it’s layered with other products. Here’s how to maximize wear:

Before Powder

Many people assume sprays are a final step, but spraying lightly before applying powder can:

• Help powder blend more smoothly

• Prevent a cakey finish

• Give a soft, seamless effect for blush, bronzer, or highlighter

Pro Tip: Spray a fine mist over your face, let it absorb for a few seconds, then apply powder lightly with a fluffy brush.

After Makeup

Applying a setting spray as a final step is crucial. It locks in everything you applied and:

• Reduces fading and smudging

• Helps eyeshadow, eyeliner, and lip products stay in place

• Gives a natural finish, whether matte or dewy

Pro Tip: Hold the spray 8–12 inches away from your face for an even mist. Spray in an X and T pattern to cover all areas evenly.

Mid-Day Refresh

Some sprays are excellent for refreshing makeup without reapplying foundation or powder. Hydrating sprays work best for this purpose.

Pro Tip: Use a light mist to revive your makeup during the day. Close your eyes, hold the bottle at arm’s length, and lightly mist the face to prevent wet patches.

Seasonal Adjustments for Setting Spray

Your choice of spray and application method should also change depending on the season:

Summer

• Heat and humidity increase oil production

• Opt for mattifying sprays that keep your makeup in place

• Avoid overly heavy layers, which can feel sticky in high heat

Extra Tip: Spritz lightly over powder to prevent makeup from melting in the sun.

Winter

• Cold air and indoor heating dry the skin

• Hydrating sprays prevent makeup from looking flaky

• Dewy or luminous sprays can add natural radiance to dry, dull skin

Extra Tip: Spray after powder or after makeup as a final step to melt products together and enhance hydration.

Transitional Seasons

• Spring and fall can combine oiliness and dryness

• Use a lightweight balancing spray that controls shine without drying cheeks or jawline

Pro Tip: Consider experimenting with layering two sprays: a hydrating mist first, then a light mattifying mist on oily areas.

Long-Wear Strategies for Busy Days

For days when you need your makeup to stay fresh for 12–16 hours, such as weddings, workdays, or long events:

1. Start With Primer: A mattifying or hydrating primer helps foundation adhere better.

2. Use Long-Wear Foundation: This complements the spray’s hold.

3. Powder Strategically: Lightly set foundation with powder in oil-prone areas.

4. Apply Setting Spray After Powder: Locks everything in place.

5. Reapply Mid-Day: For hydrating sprays, a quick spritz can refresh the look without disturbing makeup.

Pro Tip: Combining a primer, long-wear foundation, powder, and a good setting spray can extend wear for 16+ hours.

Common Mistakes People Make With Setting Spray

Even the best drugstore sprays won’t perform if applied incorrectly:

• Spraying too close: Can leave wet spots or disturb makeup.

• Overusing spray: Heavy layers can cause product to slide or feel sticky.

• Skipping hydration: Dry skin can make powder or foundation appear cakey without a hydrating spray.

• Using the wrong finish: Matte sprays on dry skin or dewy sprays on oily skin can emphasize problems.

• Rubbing or patting after spraying: This disrupts the makeup and reduces the hold.

Insider Tips for Mature and Sensitive Skin

For women over 40, setting spray can enhance the overall look of makeup if applied carefully:

• Hydrating formulas: Prevent makeup from emphasizing fine lines.

• Light misting: Heavy spraying can settle into creases.

• Layer with lightweight primer: Helps makeup stick without tugging on delicate skin.

• Spray after powder: Creates a natural, smooth finish that blends all products together.

For sensitive skin, choose fragrance-free, alcohol-free sprays to avoid irritation or dryness.

Drugstore Sprays That Are Surprisingly Effective

It’s amazing how much performance you can get from affordable sprays. Some top picks include:

• NYX Professional Makeup Setting Spray (Matte and Dewy): Cult favorites that offer reliable hold and shine control.

• Milani Make It Last: Affordable, long-wearing, hydrating, and versatile.

• e.l.f. Matte Magic Mist & Set: Great for oily skin with a smooth finish.

• Wet n Wild Photo Focus Spray: Excellent value and long-lasting results.

• L’Oreal Infallible Pro-Spray & Set: Lightweight, non-sticky, and durable.

These sprays often perform just as well as high-end alternatives but at a fraction of the price.

Tips for Maximizing Setting Spray Performance

1. Shake Well: Some sprays separate; shaking ensures even distribution.

2. Use Fine Mist: Avoid puddling or saturating the face.

3. Spray in Layers: A thin first layer, followed by a second layer if needed, keeps finish natural.

4. Set Eyes Separately: Spray lightly over eyelids after eyeshadow to lock it in.

5. Consider Skin Needs: Dewy, hydrating, or mattifying formulas should match skin type and season.

Final Thoughts

A good drugstore setting spray is an essential tool in any makeup routine. From controlling shine to hydrating dry skin, these affordable products can dramatically improve your makeup’s appearance and longevity.

Whether you’re dealing with oily T-zones, dry cheeks, or mature skin prone to fine lines, there’s a spray designed to meet your needs. Pair it with the right primer, foundation, and powder, and your makeup can last all day — looking fresh and natural.

Drugstore sprays prove that you don’t need to spend a fortune to get professional results. The key is knowing your skin type, choosing the right formula, and applying it properly. A little mist goes a long way in keeping your makeup flawless, vibrant, and fresh from morning to night.

With the 17 best drugstore setting sprays outlined here, you can confidently lock in your makeup, feel refreshed throughout the day, and enjoy all the benefits of long-lasting, beautiful coverage all without breaking your budget.